NAD+ Secret of Human Longevity

NAD+ is a coenzyme present in all biological cells, and its concentration and quantity can affect the cellular aging process. Numerous studies have shown that increasing NAD+ levels can improve insulin sensitivity, reverse mitochondrial dysfunction, and extend lifespan. There are three methods to increase NAD+ levels: activating enzymes that promote NAD+ synthesis, inhibiting enzymes that degrade NAD+, such as CD38, and supplementing NAD+ precursors, including nucleotide precursors NR and NMN.

Taken orally, NMN is rapidly absorbed and converted to NAD+. In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. 

In numerous mouse models of disease and aging, NMN has demonstrated a wide array of remarkable effects, benefitting conditions ranging from diabetes to Alzheimer’s disease to ischemia. David Sinclair, Harvard University’s noted anti-aging researcher, whose research on resveratrol, NAD+ and sirtuins is world renowned, is also conducting human trials. He is taking NMN himself; he has said his lipid profile has improved dramatically and he feels more energetic and that his blood markers, at nearly 60 years old, are closer to those of a 31-year-old.

FULL ARTICLE：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238909/